Catherine O’Hara’s performance in “Home Alone” is one of her best remembered.

With a single line, Catherine O’Hara was cemented into Hollywood history. Her panicked delivery of “Kevin!” in “Home Alone” and “Home Alone 2: Lost in New York,” with her eyes looking directly into the camera, has been referenced constantly in the 30-plus years since the first film premiered. So much so, in fact, that the last few holiday seasons O’Hara was seen with Kevin Hart parodying the line in a series of Chase Bank commercials.

That would have been enough for just about any performer to have had a worthwhile career. It only takes one memorable pop culture moment, after all. But O’Hara, who died on Jan. 30, had many. Virtually every second she was on screen in her Emmy-winning role on “Schitt’s Creek” was turned into a meme. The “Day-o” number in “Beetlejuice” brought lip syncing to hilarious heights. The stop-motion Sally won over hearts in “The Nightmare Before Christmas.”

Perhaps no performer in Christopher Guest’s reliable ensemble made a greater mark than O’Hara did in “Waiting for Guffman,” “Best in Show,” “A Mighty Wind” and “For Your Consideration.” Just last year, she starred on two TV series, polar opposite in tone, “The Studio” and “The Last of Us.” And, of course, O’Hara initially endeared herself to audiences with a treasure trove of hilarious characters on “SCTV.”

Following her death at 71 – which representatives said followed a brief illness – an outpouring of tributes came from the many luminaries with whom she crossed paths. O’Hara, who was named honorary mayor of her longtime home of Brentwood in 2021, was a Toronto native. Onstage following a show with Steve Martin, fellow Canadian Martin Short said, “Catherine O’Hara, I met when she was 18 years of age … and all these years later, she has been the greatest, most brilliant, kindest, sweetest angel that any of us worked with.”

Frequent co-star Eugene Levy said in a statement that “words seem inadequate to express the loss I feel.”

“I had the honor of knowing and working with the great Catherine O’Hara for over [50] years,” he continued. “From our beginnings on the Second City stage, to ‘SCTV,’ to the movies we did with Chris Guest, to our six glorious years on ‘Schitt’s Creek,’ I cherished our working relationship, but most of all our friendship.”

Levy’s son, Dan, who co-created “Schitt’s Creek” and played her son on the series, said, in part, that it was “a gift to have gotten to dance in the warm glow of Catherine O’Hara’s brilliance for all those years.”

Fellow “The Last of Us” performer Pedro Pascal wrote on Instagram, “Oh, genius to be near you. Eternally grateful. There is less light in my world, this lucky world that had you, will keep you, always. Always.”

“Beetlejuice” himself, Michael Keaton, wrote, “She’s been my pretend wife, my pretend nemesis and my real life, true friend. This one hurts. Man am I gonna miss her.”

“Getting to work with her was a true honour. She was hysterical, kind, intuitive, generous… she made me want to make our show good enough to be worthy of her presence in it,” “The Studio” co-creator and star Seth Rogen said. “This is just devastating. We’re all lucky we got to live in a world with her in it.”

“I’m stunned and heartbroken, along with the rest of the world,” “Home Alone” director Chris Columbus wrote. “I was an obsessive fan of Catherine’s brilliant comedic work on ‘SCTV’ and was thrilled when she agreed to play Kevin’s mom in ‘Home Alone.’ What most people don’t realize is that Catherine carries the weight of 50 percent of that film. The movie simply would not work without   her extraordinary performance. Catherine grounds the picture with a profound emotional depth. I will miss her greatly. Yet there is a small sense of comfort, realizing that two of the finest human beings I’ve ever known, Catherine and John Candy, are together again, brilliantly improvising, making each other laugh.”

As for Macaulay Culkin, the other half of “Home Alone,” the former child star shared photos of the two together, both on set in 1990 and at Culkin’s 2023 Hollywood Walk of Fame ceremony.

“Mama. I thought we had time. I wanted more,” Culkin wrote on Instagram. “I wanted to sit in a chair next to you. I heard you but I had so much more to say. I love you. I’ll see you later.”